![]() ![]() 5, 6 Hs-cTn has several potential advantages over conventional EP biomarkers. Traditionally, troponin measurements have been used for the diagnosis of myocardial infarction (MI) however, new highly sensitive assays may add important prognostic information regarding cardiovascular risk in various symptomatic and asymptomatic populations. 4 An emerging electrophysiology (EP) biomarker that has shown substantial promise is high-sensitivity cardiac troponin (hs-cTn). ![]() 2, 3 In this context, cardiac biomarkers may add important prognostic information, thereby augmenting and personalizing quantitative risk assessment in the prevention and management of arrhythmias. 1 Although many demographic and clinical variables have been associated with the future development of cardiac arrhythmias and their sequelae-most notably stroke, heart failure, and sudden cardiac death (SCD)-the prognostic value of these variables is often limited in clinical care. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).Ĭardiac arrhythmias remain a significant source of cardiovascular morbidity and mortality with an overall prevalence of 5.3% in the general adult population and a prevalence of up to 40% among patients attending cardiology clinics. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays-which detect subclinical cardiac myocyte damage-in cardiac arrhythmias and their sequelae. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. ![]()
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